Integrated testing strategies for safety assessments
نویسندگان
چکیده
منابع مشابه
Food for Thought ... Integrated Testing Strategies for Safety Assessments
Replacing a test on a living organism with a cellular, chemicoanalytical, or computational approach obviously is reductionistic. Sometimes this might work well, e.g., when an extreme pH is a clear indication of corrosivity. In general, however, it is naïve to expect a single system to substitute for all mechanisms, the entire applicability domain (substance classes), and degrees of severity. St...
متن کاملIntegrated Testing Strategies (ITS) for safety assessment.
Integrated testing strategies (ITS), as opposed to single definitive tests or fixed batteries of tests, are expected to efficiently combine different information sources in a quantifiable fashion to satisfy an information need, in this case for regulatory safety assessments. With increasing awareness of the limitations of each individual tool and the development of highly targeted tests and pre...
متن کاملIntegrated Testing Strategies ( ITS ) for Safety Assessment 1
CAAT Europe, University of Konstanz, Germany; L’Oréal R&I, Aulnay, France; Research Institute for Fragrance Materials, Inc., Woodcliff Lake, USA; DABMEB Consultancy Ltd, Sharnbrook, UK; INERIS, DRC/VIVA/METO, Verneuil en Halatte, France; Università degli Studi di Milano, Department of Health, Animal Science and Food Safety (VESPA), Milan, Italy; Università degli Studi di Milano, Department of P...
متن کاملSafety Effectiveness of Integrated Accident Prevention Strategies
There are potential interactions among approaches to reduce or prevent certain accident causes. Given the overlapped safety benefits of various measures for accident prevention, it is necessary to identify their interactions and quantify the safety effectiveness of combined accident prevention strategies. This study focuses on strategies to prevent broken rails and broken wheels, respectively. ...
متن کاملAlternative Safety Testing Strategies for Acellular Pertussis Vaccines
77 Infection by the Gram-negative bacterium Bordetella pertussis can lead to the development of pertussis, also known as whooping cough due to the characteristic sound infected infants make following a severe coughing fit. Infection by B. pertussis is fairly common, but it rarely causes serious complications in adults. However, the infection can be fatal in infants and young children if left un...
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ژورنال
عنوان ژورنال: ALTEX
سال: 2013
ISSN: 1868-596X
DOI: 10.14573/altex.2013.1.003